Physiology and pathophysiology of human airway mucus
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …
harbors a large and diverse microbial population collectively called the gut microbiome …
Targeting cell signaling in allergic asthma
SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
Airway mucus and asthma: the role of MUC5AC and MUC5B
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and
metaplasia result in changes in stored and secreted mucin and the production of a …
metaplasia result in changes in stored and secreted mucin and the production of a …
Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways
Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus
layer of human airways. Each mucin has distinct functions and site-specific expression …
layer of human airways. Each mucin has distinct functions and site-specific expression …
Muc5b is required for airway defence
MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee… - Nature, 2014 - nature.com
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A
protective mucus barrier traps and eliminates them through mucociliary clearance (MCC) …
protective mucus barrier traps and eliminates them through mucociliary clearance (MCC) …
Airway mucus function and dysfunction
JV Fahy, BF Dickey - New England journal of medicine, 2010 - Mass Medical Soc
Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …
Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways
CM Evans, TE Fingerlin, MI Schwarz… - Physiological …, 2016 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is an incurable complex genetic disorder that is
associated with sequence changes in 7 genes (MUC5B, TERT, TERC, RTEL1, PARN …
associated with sequence changes in 7 genes (MUC5B, TERT, TERC, RTEL1, PARN …
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
CM Evans, DS Raclawska, F Ttofali, DR Liptzin… - Nature …, 2015 - nature.com
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered
airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle …
airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle …
[HTML][HTML] Cell biology of disease: The cell biology of asthma
DJ Erle, D Sheppard - The Journal of cell biology, 2014 - ncbi.nlm.nih.gov
The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …