Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Histamine is a biogenic amine with extensive effects on many cell types, including important
immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

The efficacy of a drug is generally determined by the drug's ability to promote a quantifiable
biological response. In the context of the classical receptor-occupancy theory, the efficacy is …

Drug efficacy is typically considered an intrinsic property of a ligand/receptor couple.
However, recent observations suggest that efficacy may also be influenced by the signaling …

Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic …

Histamine H 3 receptor pharmacology, functions and biochemistry are far from being fully
understood; however, progress is being made. Activation of this G i/G o-protein-coupled …

The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile
group of cell surface receptors. Drugs active at these receptors have therapeutic actions …

Histamine H3 receptor inverse agonists are known to enhance the activity of histaminergic
neurons in brain and thereby promote vigilance and cognition. 1-{3-[3-(4-Chlorophenyl) …