Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Single-cell RNA sequencing is a powerful tool to study developmental biology but does not
preserve spatial information about tissue morphology and cellular interactions. Here, we …

The cardiac vascular and perivascular niche are of major importance in homeostasis and
during disease, but we lack a complete understanding of its cellular heterogeneity and …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of
different acute (myocardial infarction) or chronic (diabetes, hypertension,…) diseases but …

Despite relevant advances made in therapies for cardiovascular diseases (CVDs), they still
represent the first cause of death worldwide. Cardiac fibrosis and excessive extracellular …

Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha
(DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential …

Myocardial infarction is remains the leading cause of death in developed countries. Recent
data show that the composition of the extracellular matrix might differ despite similar heart …

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, a novel class of hypoglycemic drugs,
show excellent cardiovascular benefits, and have further improved heart failure outcomes …