Confounding by indication poses a significant threat to the validity of nonexperimental
studies assessing effectiveness and safety of medical interventions. While no different from …

Much has been written about real-world evidence (RWE), a concept that offers an
understanding of the effects of healthcare interventions using routine clinical data. The …

Background Opioid agonist therapy is strongly recommended for pregnant persons with
opioid use disorder. Buprenorphine may be associated with more favorable neonatal and …

Thrombotic complications occur at high rates in hospitalized patients with COVID‐19, yet the
impact of intensive antithrombotic therapy on mortality is uncertain. We examined in‐hospital …

Importance The comparative effectiveness of rivaroxaban and apixaban, the most frequently
prescribed oral anticoagulants for ischemic stroke prevention in patients with atrial …

Objective To study the effectiveness and safety of the non-vitamin K antagonist oral
anticoagulants (novel oral anticoagulants, NOACs) dabigatran, rivaroxaban, and apixaban …

Objective To investigate the associations between direct oral anticoagulants (DOACs) and
risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality …

Importance Patients diagnosed with localized prostate cancer have to decide among
treatment strategies that may differ in their likelihood of adverse effects. Objective To …

Objective To examine clinical effectiveness and safety of apixaban 2.5 mg, dabigatran 110
mg, and rivaroxaban 15 mg compared with warfarin among patients with atrial fibrillation …

Background & Aims There have been conflicting results from studies comparing the risk of
hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection …