The key to gametogenesis is the proper execution of a specialized form of cell division
named meiosis. Prior to the meiotic divisions, the recombination of maternal and paternal …

Meiosis poses unique challenges because two rounds of chromosome segregation must be
executed without intervening DNA replication. Mammalian cells express numerous …

Chromosome segregation is driven by separase, activity of which is inhibited by binding to
securin and cyclin B1/CDK1. In meiosis, premature separase activity will induce aneuploidy …

Successful cell division relies on the timely removal of key cell cycle proteins such as
securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes …

To generate haploid gametes, cohesin is removed in a stepwise manner from chromosome
arms in meiosis I and the centromere region in meiosis II to segregate chromosomes and …

Partitioning of the genome in meiosis occurs through two highly specialized cell divisions,
named meiosis I and meiosis II. Step‐wise cohesin removal is required for chromosome …

Successful cell division relies on the faithful segregation of chromosomes. If chromosomes
segregate prematurely the cell is at risk of aneuploidy. Alternatively, if cell division is …

Chromosome segregation during female meiosis is frequently incorrect with severe
consequences including termination of further development or severe disorders, such as …

Here, we describe a biosensor to assess meiotic cohesin subunit Rec8 cleavage in mouse
oocytes. We detail oocyte collection and microinjection of the mRNA expressing the …

Live-cell imaging is a powerful method to obtain insights into cellular processes, particularly
with respect to their dynamics. This is especially true for meiosis, where chromosomes and …