Immune cells use a variety of membrane-disrupting proteins [complement, perforin, perforin-
2, granulysin, gasdermins, mixed lineage kinase domain–like pseudokinase (MLKL)] to …

Redox-active, strongly magnetic, combustion and friction-derived nanoparticles (CFDNPs)
are abundant in particulate matter air pollution. Urban children and young adults with …

CD59 is an abundant immuno-regulatory receptor that protects human cells from damage
during complement activation. Here we show how the receptor binds complement proteins …

Abstract Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that
functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to …

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills
pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of …

C-Mannosylation is a post-translational modification of proteins in the endoplasmic
reticulum. Monomeric α-mannose is attached to specific Trp residues at the first Trp in the …

Unregulated complement activation causes inflammatory and immunological pathologies
with consequences for human disease. To prevent bystander damage during an immune …

The interactions of cancer cells with components of the complement system are highly
complex, leading to an outcome that is either favorable or detrimental to cancer cells …

Dermatomyositis and polymyositis (DM/PM) are systemic autoimmune diseases
characterized by proximal muscle weakness. The underlying pathogenetic mechanism of …

The human immune system can directly lyse invading micro‐organisms and aberrant host
cells by generating pores in the cell envelope, called membrane attack complexes (MACs) …