The human brain is the continuous subject of extensive investigation aimed at
understanding its behavior and function. Despite a clear evidence that mechanical factors …

Cortical folding, or gyrification, coincides with several important developmental processes.
The folded shape of the human brain allows the cerebral cortex, the thin outer layer of …

In brain imaging, accurate alignment of cortical surfaces is fundamental to the statistical
sensitivity and spatial localisation of group studies, and cortical surface-based alignment …

Convolutions are a classical hallmark of most mammalian brains. Brain surface morphology
is often associated with intelligence and closely correlated with neurological dysfunction …

The developing human brain remains one of the few unsolved mysteries of science.
Advancements in developmental biology, neuroscience and medical imaging have brought …

Folding of the cerebral cortical surface is a critical process in human brain development, yet
despite decades of indirect study and speculation the mechanics of the process remain …

In humans and many other mammals, the cortex (the outer layer of the brain) folds during
development. The mechanics of folding are not well understood; leading explanations are …

Gyrification, the developmental buckling of the cortex, is not a random process—the forces
that mediate expansion do so in such a way as to generate consistent patterns of folds …

Why the cerebral cortex folds in some mammals but not in others has long fascinated and
mystified neurobiologists. Over the past century—especially the past decade—researchers …

Improved understanding of the factors that govern folding of the cerebral cortex is desirable
for many reasons. The existence of consistent patterns in folding within and between …