In recent years, peptide-coupling reactions have significantly advanced in parallel with the
development of new peptidecoupling reagents, which have been covered in a number of …

Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …

Molecular rearrangements are a powerful tool for constructing complex structures in an atom-
and step-economic manner, translating multistep transformations into an intrinsically more …

This work is not a typical review that is trying to cover all coupling reagents in-depth. This is
a personal account—it is written in the first person—seeking to summarize the 25 years of …

Peptide bonds, the amide bonds formed between α-amino acids, constitute the backbone of
peptides and proteins. Although peptide bonds can be constructed efficiently under mild …

Peptides are an increasingly important group of pharmaceuticals, positioned between
classic small organic molecules and larger bio-molecules such as proteins. Currently, the …

An approach using water as a solvent (coupling and deprotection) was developed for the
solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key …

In this study, the solvation effects, and spectroscopic characterization of the N-(9-
Fluorenylmethoxycarbonyloxy) succinimide (Fmoc-OSu) were described using experimental …

Peptides are a fast growing segment in the pharmaceutical industry. Consequently, the
industry and regulatory agencies are increasing their focus on the regulatory path and …

In order to understand the chemical speciation of 2-mercaptobenzothiazole (MBT) corrosion
inhibitor as a function of pH, the experimental electronic absorption spectra was compared …