It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Quantification of the human painful sensory experience is an essential step in the translation
of knowledge from animal nociception to human pain. Translational models for assessment …

Prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, is the best known lipid mediator
that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) …

The beneficial actions of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been linked to
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …

The enzyme cyclooxygenase (COX) catalyzes the first step of the synthesis of prostanoids. In
the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is …

GERD and Esophageal Motility Disorders Esophageal motility disorders and esophageal
reflux are common, produce a wide range of symptoms, and compromise quality of life …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Visceral hypersensitivity (perception of gastrointestinal sensory events at a lower‐than‐
normal threshold) is considered to be an important pathophysiological mechanism in the …

Non-erosive reflux disease (NERD) is defined as the presence of classic symptoms of gastro-
oesophageal reflux disease (GORD) in the absence of oesophageal mucosal injury (or …

Background & Aims: Visceral hypersensitivity is a common feature of functional
gastrointestinal disorders. One speculated mechanism is an activity-dependent increase in …