Mitochondria as a cellular hub in infection and inflammation

P Andrieux, C Chevillard, E Cunha-Neto… - International journal of …, 2021 - mdpi.com
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Structural characterization of SARS-CoV-2: where we are, and where we need to be

G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

Decoding type I and III interferon signalling during viral infection

EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Mitochondrial functions in infection and immunity

V Tiku, MW Tan, I Dikic - Trends in cell biology, 2020 - cell.com
Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …

Rewiring cellular networks by members of the Flaviviridae family

CJ Neufeldt, M Cortese, EG Acosta… - Nature Reviews …, 2018 - nature.com
Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a
single-strand RNA genome of positive polarity. Several genera belong to this family …

Ten strategies of interferon evasion by viruses

A García-Sastre - Cell host & microbe, 2017 - cell.com
Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway

C Ritchie, JA Carozza, L Li - Annual Review of Biochemistry, 2022 - annualreviews.org
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

SJF Kaptein, O Goethals, D Kiemel, A Marchand… - Nature, 2021 - nature.com
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting
as dengue fever or occasionally as severe dengue,. There are no antiviral agents available …

Structural basis of mitochondrial receptor binding and constriction by DRP1

R Kalia, RYR Wang, A Yusuf, PV Thomas, DA Agard… - Nature, 2018 - nature.com
Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on
organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors …

Dengue virus and the host innate immune response

N Uno, TM Ross - Emerging microbes & infections, 2018 - Taylor & Francis
Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …