Periodontal disease is a major public health issue, and various periodontal therapies have
been performed to regenerate periodontal tissues. The periodontium is a complex structure …

There is significant interest in understanding the cellular mechanisms responsible for
expedited healing response in various oral tissues and how they are impacted by systemic …

Aging has been reported to deteriorate the quantity and quality of mesenchymal stem cells
(MSCs), which affect their therapeutic use in regenerative medicine. A dearth of age-related …

Adult human gingival fibroblasts (HGFs), the most abundant cells in the oral cavity, are
essential for maintaining oral homeostasis. Compared with other tissues, adult oral mucosal …

Soft tissue reconstruction has remained a major clinical challenge in dentistry and
regenerative medicine. Although current methods have shown partial success, there are …

Although the application of stem cells to chronic wounds emerged as a candidate therapy in
the previous century, the mechanism of action remains unclear. Recent evidence has …

Objectives The gingiva heals at an accelerated rate with reduced scarring when compared
to skin. Potential well-studied factors include immune cell number, angiogenesis disparities …

Significance: Skin inevitably heals with the formation of a fibrotic scar. Patients affected by
skin scarring suffer from long-term psychological and physical burdens. Recent Advances …

Hemorrhagic shock/resuscitation (HS/R) is closely associated with overwhelming oxidative
stress and systemic inflammation. As an effective activator of the nuclear factor-erythroid …

Considering the complex process of wound healing, it is expected that an optimal wound
dressing should be able to overcome the multiple obstacles that can be encountered in the …