Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …
Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …
interconnected research fields. These include the development of new materials with a …
Protective actions of sex steroid hormones in Alzheimer's disease
CJ Pike, JC Carroll, ER Rosario, AM Barron - Frontiers in …, 2009 - Elsevier
Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …
hormones in both women and men. In post-menopausal women, the precipitous depletion of …
The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal …
JT Dalton, KG Barnette, CE Bohl, ML Hancock… - Journal of cachexia …, 2011 - Springer
Background Cachexia, also known as muscle wasting, is a complex metabolic condition
characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting …
characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting …
Study design and rationale for the phase 3 clinical development program of enobosarm, a selective androgen receptor modulator, for the prevention and treatment of …
J Crawford, CMM Prado, MA Johnston, RJ Gralla… - Current oncology …, 2016 - Springer
Muscle wasting in cancer is a common and often occult condition that can occur prior to
overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle …
overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle …
Selective androgen receptor modulators as function promoting therapies
S Bhasin, R Jasuja - Current Opinion in Clinical Nutrition & …, 2009 - journals.lww.com
Selective androgen receptor modulators as function promoting... : Current Opinion in Clinical
Nutrition & Metabolic Care Selective androgen receptor modulators as function promoting …
Nutrition & Metabolic Care Selective androgen receptor modulators as function promoting …
Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit
ML Mohler, CE Bohl, A Jones, CC Coss… - Journal of medicinal …, 2009 - ACS Publications
Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past …
androgen receptor modulators (SARMs) a has increased dramatically within the past …
Selective androgen receptor modulators in preclinical and clinical development
R Narayanan, ML Mohler, CE Bohl… - Nuclear receptor …, 2008 - journals.sagepub.com
Androgen receptor (AR) plays a critical role in the function of several organs including
primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable …
primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable …
Targeting the androgen receptor in breast cancer
The androgen receptor (AR) is expressed in the majority of breast cancer and across the
three main breast cancer subtypes. Historically, the oncogenic role of AR has best been …
three main breast cancer subtypes. Historically, the oncogenic role of AR has best been …
[HTML][HTML] Discovery and therapeutic promise of selective androgen receptor modulators
J Chen, J Kim, JT Dalton - Molecular interventions, 2005 - ncbi.nlm.nih.gov
Androgens are essential for male development and the maintenance of male secondary
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …
Detection of SARMs in doping control analysis
M Thevis, W Schänzer - Molecular and cellular endocrinology, 2018 - Elsevier
The class of selective androgen receptor modulators (SARMs) has been the subject of
intense and dedicated clinical research over the past two decades. Potential therapeutic …
intense and dedicated clinical research over the past two decades. Potential therapeutic …