Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …

Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Protective actions of sex steroid hormones in Alzheimer's disease

CJ Pike, JC Carroll, ER Rosario, AM Barron - Frontiers in …, 2009 - Elsevier
Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal …

JT Dalton, KG Barnette, CE Bohl, ML Hancock… - Journal of cachexia …, 2011 - Springer
Background Cachexia, also known as muscle wasting, is a complex metabolic condition
characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting …

Study design and rationale for the phase 3 clinical development program of enobosarm, a selective androgen receptor modulator, for the prevention and treatment of …

J Crawford, CMM Prado, MA Johnston, RJ Gralla… - Current oncology …, 2016 - Springer
Muscle wasting in cancer is a common and often occult condition that can occur prior to
overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle …

Selective androgen receptor modulators as function promoting therapies

S Bhasin, R Jasuja - Current Opinion in Clinical Nutrition & …, 2009 - journals.lww.com
Selective androgen receptor modulators as function promoting... : Current Opinion in Clinical
Nutrition & Metabolic Care Selective androgen receptor modulators as function promoting …

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

ML Mohler, CE Bohl, A Jones, CC Coss… - Journal of medicinal …, 2009 - ACS Publications
Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past …

Selective androgen receptor modulators in preclinical and clinical development

R Narayanan, ML Mohler, CE Bohl… - Nuclear receptor …, 2008 - journals.sagepub.com
Androgen receptor (AR) plays a critical role in the function of several organs including
primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable …

Targeting the androgen receptor in breast cancer

KM Chia, M O'Brien, M Brown, E Lim - Current oncology reports, 2015 - Springer
The androgen receptor (AR) is expressed in the majority of breast cancer and across the
three main breast cancer subtypes. Historically, the oncogenic role of AR has best been …

[HTML][HTML] Discovery and therapeutic promise of selective androgen receptor modulators

J Chen, J Kim, JT Dalton - Molecular interventions, 2005 - ncbi.nlm.nih.gov
Androgens are essential for male development and the maintenance of male secondary
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …

Detection of SARMs in doping control analysis

M Thevis, W Schänzer - Molecular and cellular endocrinology, 2018 - Elsevier
The class of selective androgen receptor modulators (SARMs) has been the subject of
intense and dedicated clinical research over the past two decades. Potential therapeutic …