The hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the main cause of two
tightly linked neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with an extremely
heterogeneous clinical and genetic phenotype. In our efforts to find therapies for ALS, the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically
distinct classes of neurodegenerative disorders. Yet, they share a range of genetic, cellular …

Trimethyltin chloride (TMT) is widely used as a constituent of fungicides and plastic
stabilizers in the industrial and agricultural fields, and is generally acknowledged to have …

Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron
disease. The disease is characterized by protein aggregates. The symptoms include …

The GGGGCC intronic repeat expansion within C9ORF72 is the most common genetic
cause of ALS and FTD. This mutation results in toxic gain of function through accumulation …

A pathogenic GGGCCC hexanucleotide expansion in the first intron/promoter region of the
C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis …

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease caused by
degeneration of motor neurons (MNs). ALS pathogenic features include accumulation of …

A major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia
(FTD) spectrum disorder is the hexanucleotide G4C2 repeat expansion in the first intron of …