Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods,
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …

Plant-parasitic nematodes are costly burdens of crop production. Ubiquitous in nature,
phytoparasitic nematodes are associated with nearly every important agricultural crop and …

RNA therapeutics involve the use of coding RNA such as mRNA as well as non-coding
RNAs such as small interfering RNAs (siRNA), antisense oligonucleotides (ASO) to target …

Since long before the first approval of gene therapy for retinal disease, ocular gene therapy
has captured the hopes of patients, clinicians, and scientists alike. Indeed, the retina …

Rapid detection of nucleic acids (DNA or RNA) by inexpensive, selective, accurate, and
highly sensitive methods is very important for biosensors. DNA-sensors based on DNA …

CRISPR/Cas9 technology has become the most examined gene editing technology in
recent years due to its simple design, yet low cost, high efficiency, and simple operation …

The emergence of multi-drug resistance (MDR) to pan-drug resistance (PDR) in
Enterobacteriaceae has made treatment extremely challenging. Genetic mutations and …

Salmonella is recognized as one of the most common microbial pathogens worldwide. The
bacterium contains the clustered regularly interspaced short palindromic repeats (CRISPR) …