[HTML][HTML] Chitosan nanoparticles at the biological interface: implications for drug delivery
N Aibani, R Rai, P Patel, G Cuddihy, EK Wasan - Pharmaceutics, 2021 - mdpi.com
The unique properties of chitosan make it a useful choice for various nanoparticulate drug
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …
Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy
Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins
The intracellular delivery of biofunctional enzymes or therapeutic proteins through systemic
administration is of great importance in therapeutic intervention of various diseases …
administration is of great importance in therapeutic intervention of various diseases …
Endosomal escape pathways for delivery of biologicals
Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …
efficient and specific delivery of targeted therapeutic agents still remains an issue in …
Application of chitosan and chitosan derivatives as biomaterials
C Choi, JP Nam, JW Nah - Journal of Industrial and Engineering Chemistry, 2016 - Elsevier
Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked d-
glucosamine and N-acetyl-d-glucosamine. It is one of the major cationic polymers and the …
glucosamine and N-acetyl-d-glucosamine. It is one of the major cationic polymers and the …
Chitosan and chitosan derivatives in drug delivery and tissue engineering
R Riva, H Ragelle, A des Rieux, N Duhem… - … for biomaterials II, 2011 - Springer
Chitosan is a nontoxic, biodegradable, and biocompatible polysaccharide of β (1-4)-linked d-
glucosamine and N-acetyl-d-glucosamine. This derivative of natural chitin presents …
glucosamine and N-acetyl-d-glucosamine. This derivative of natural chitin presents …
Challenges in DNA delivery and recent advances in multifunctional polymeric DNA delivery systems
After more than 20 years of intensive investigations, gene therapy has become one of the
most promising strategies for treating genetic diseases. However, the lack of ideal delivery …
most promising strategies for treating genetic diseases. However, the lack of ideal delivery …
Chitosan-based drug nanocarriers: where do we stand?
M Garcia-Fuentes, MJ Alonso - Journal of Controlled Release, 2012 - Elsevier
Chitosan-based nanocarriers have become one of the most intensively studied
transmucosal nanometric drug delivery platforms. This is due to a number of factors …
transmucosal nanometric drug delivery platforms. This is due to a number of factors …
Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine
HY Xue, S Liu, HL Wong - Nanomedicine, 2014 - Taylor & Francis
siRNAs have immense therapeutic potential for the treatment of various gene-related
diseases ranging from cancer, viral infections and neuropathy to autoimmune diseases …
diseases ranging from cancer, viral infections and neuropathy to autoimmune diseases …
Chitosans for delivery of nucleic acids
MD Buschmann, A Merzouki, M Lavertu… - Advanced drug delivery …, 2013 - Elsevier
Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …