Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

FM Gribble, F Reimann - Nature Reviews Endocrinology, 2019 - nature.com
Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

The influence of the gut microbiome on host metabolism through the regulation of gut hormone release

AM Martin, EW Sun, GB Rogers, DJ Keating - Frontiers in physiology, 2019 - frontiersin.org
The microbial community of the gut conveys significant benefits to host physiology. A clear
relationship has now been established between gut bacteria and host metabolism in which …

The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine

N Liu, S Sun, P Wang, Y Sun, Q Hu… - International journal of …, 2021 - mdpi.com
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

The ever-changing roles of serotonin

LA Jones, EW Sun, AM Martin, DJ Keating - The international journal of …, 2020 - Elsevier
Abstract Serotonin (5-HT) has traditional roles as a key neurotransmitter in the central
nervous system and as a regulatory hormone controlling a broad range of physiological …

The role of serotonin neurotransmission in gastrointestinal tract and pharmacotherapy

T Guzel, D Mirowska-Guzel - Molecules, 2022 - mdpi.com
5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain

S Battaglia, C Nazzi, JF Thayer - Translational psychiatry, 2024 - nature.com
Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is
a physiological index observable in humans, especially in fear conditioning experiments …

Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies

B Waclawiková, A Codutti, K Alim, S El Aidy - Gut microbes, 2022 - Taylor & Francis
The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities
have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial …

Serotonin neurons modulate learning rate through uncertainty

CD Grossman, BA Bari, JY Cohen - Current Biology, 2022 - cell.com
Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

[HTML][HTML] Role of serotonin receptor signaling in cancer cells and anti-tumor immunity

S Karmakar, G Lal - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect
emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases …

The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling

J Wang, W Xu, R Wang, R Cheng, Z Tang, M Zhang - Food & Function, 2021 - pubs.rsc.org
Akkermansia muciniphila is a probiotic inhabiting host intestinal mucus layers and displays
evident easing or therapeutic effects on host enteritis and metabolic disorders such as …