CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids

D Hendriks, H Clevers, B Artegiani - Cell stem cell, 2020 - cell.com
CRISPR-Cas technology has revolutionized biological research and holds great therapeutic
potential. Here, we review CRISPR-Cas systems and their latest developments with an …

[HTML][HTML] The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

W Zhao, Y Chen, N Hu, D Long, Y Cao - Ecotoxicology and Environmental …, 2024 - Elsevier
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish
(Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about …

Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors

X Wang, J Zhu, H Wang, W Deng, S Jiao… - Nature …, 2023 - nature.com
The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …

Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner

A Xie, Z Ma, J Wang, Y Zhang, Y Chen, C Yang… - Cell Discovery, 2023 - nature.com
Genetic compensation responses (GCRs) can be induced by deleterious mutations in living
organisms in order to maintain genetic robustness. One type of GCRs, homology-dependent …

Gaucher disease protects against tuberculosis

J Fan, VL Hale, LT Lelieveld… - Proceedings of the …, 2023 - National Acad Sciences
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease,
characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in …

Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation

J Wu, J Li, K Chen, G Liu, Y Zhou… - Proceedings of the …, 2023 - National Acad Sciences
Hematopoietic stem and progenitor cells (HSPCs) are a heterogeneous group of cells with
expansion, differentiation, and repopulation capacities. How HSPCs orchestrate the …

[HTML][HTML] Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set

D Ye, T Liu, Y Li, Y Wang, W Hu, Z Zhu… - Frontiers in …, 2023 - frontiersin.org
Image-based identification and quantification of different types of spermatogenic cells is of
great importance, not only for reproductive studies but also for genetic breeding. Here, we …

Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation

F Zhang, Y Hao, X Li, Y Li, D Ye, R Zhang… - Science China Life …, 2022 - Springer
The surrogate reproduction technique, such as inter-specific spermatogonial stem cells
(SSCs) transplantation (SSCT), provides a powerful tool for production of gametes derived …

Zebrafish models of craniofacial malformations: interactions of environmental factors

ST Raterman, JR Metz, FA Wagener… - Frontiers in Cell and …, 2020 - frontiersin.org
The zebrafish is an appealing model organism for investigating the genetic (G) and
environmental (E) factors, as well as their interactions (GxE), which contribute to craniofacial …

Circadian regulation of developmental synaptogenesis via the hypocretinergic system

XF Du, FN Li, XL Peng, B Xu, Y Zhang, G Li… - Nature …, 2023 - nature.com
The circadian clock orchestrates a wide variety of physiological and behavioral processes,
enabling animals to adapt to daily environmental changes, particularly the day-night cycle …