As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Background Aberrant activation of the Hedgehog pathway drives tumorigenesis of many
cancers, including glioblastoma. However, the sensitization mechanism of the G protein …

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing,
and cancer development. It involves cooperation of signaling pathways, such as …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during
embryonic development. Recently, uncontrolled activation of this pathway has been …