Caffeine is the most widely consumed centralnervous-system stimulant. Three main
mechanisms of action of caffeine on the central nervous system have been described …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Abstract Xestospongins (Xe's) A, C, D, araguspongine B, and demethylxestospongin B, a
group of macrocyclic bis-1-oxaquinolizidines isolated from the Australian sponge …

Bruton's tyrosine kinase (Btk) is essential for B‐lineage development and represents an
emerging family of non‐receptor tyrosine kinases implicated in signal transduction events …

Two classes of intracellular Ca 2+-release channels, the ryanodine reccptor and the mositol
(1, 4, 5)-trisphosphate (IP 3) receptor, are essential for spatiotemporal Ca 2+ signalling in …

Vincenzo Sorrentino and Pompeo Volpe review some recent deve~ o~ menis~ the
ryanodine receptor channels have now been found to be expressed in the central nervous …

Experimental observations indicate that Ca 2+-induced Ca 2+ release (CICR) may underlie
Ca 2+ oscillations in a variety of cells. In its original version, a theoretical model for signal …

It IS NOW accepted generally that intracellular Ca” is a crucial signal that controls many
aspects of cellular function. Neuronal Ca” signalling is particularly complex; activation of …

We find that calcium influx through voltage-dependent calcium channels causes extensive
neurite outgrowth in PC12 cells. The calcium signal transduction pathway promoting neurite …

A molecularly tagged form of calreticulin (CR), a low affinity-high capacity Ca2+ binding
protein that resides in the ER lumen, was transiently transfected into HeLa cells to …