[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Metabolic changes in aging humans: current evidence and therapeutic strategies

AK Palmer, MD Jensen - The Journal of clinical …, 2022 - Am Soc Clin Investig
Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

Effects of intermittent fasting on health, aging, and disease

R De Cabo, MP Mattson - New England Journal of Medicine, 2019 - Mass Medical Soc
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

Mechanisms of dysfunction in the aging vasculature and role in age-related disease

AJ Donato, DR Machin, LA Lesniewski - Circulation research, 2018 - Am Heart Assoc
Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential

F Madeo, D Carmona-Gutierrez, SJ Hofer, G Kroemer - Cell metabolism, 2019 - cell.com
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Dietary strategies for metabolic syndrome: a comprehensive review

S Castro-Barquero, AM Ruiz-León, M Sierra-Pérez… - Nutrients, 2020 - mdpi.com
Metabolic syndrome is a cluster of metabolic risk factors, characterized by abdominal
obesity, dyslipidemia, low levels of high-density lipoprotein cholesterol (HDL-c) …

New advances in metabolic syndrome, from prevention to treatment: the role of diet and food

D Ambroselli, F Masciulli, E Romano, G Catanzaro… - Nutrients, 2023 - mdpi.com
The definition of metabolic syndrome (MetS) has undergone several changes over the years
due to the difficulty in establishing universal criteria for it. Underlying the disorders related to …

A clinical overview of non‐alcoholic fatty liver disease: a guide to diagnosis, the clinical features, and complications—what the non‐specialist needs to know

MD Muthiah, N Cheng Han… - Diabetes, Obesity and …, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) has a rapidly rising prevalence worldwide and is
the most common cause of liver disease in developed countries. In this article, we discuss …

Concept of extremes in vascular aging: from early vascular aging to supernormal vascular aging

S Laurent, P Boutouyrie, PG Cunha, P Lacolley… - …, 2019 - Am Heart Assoc
Laurent et al Early, Normal, and Supernormal Vascular Aging 219 normally defined by the
absence of variables linked to the metabolic syndrome. 21, 22 An alternative way to define …