Functional amyloids

D Otzen, R Riek - Cold Spring Harbor perspectives in …, 2019 - cshperspectives.cshlp.org
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Molecular mechanisms and evolutionary consequences of spore killers in ascomycetes

S Zanders, H Johannesson - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
In this review, we examine the fungal spore killers. These are meiotic drive elements that
cheat during sexual reproduction to increase their transmission into the next generation …

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

A Daskalov, B Habenstein, R Sabaté… - Proceedings of the …, 2016 - National Acad Sciences
Recent findings have revealed the role of prion-like mechanisms in the control of host
defense and programmed cell death cascades. In fungi, HET-S, a cell death-inducing …

The mechanism of toxicity in HET-S/HET-s prion incompatibility

C Seuring, J Greenwald, C Wasmer, R Wepf… - PLoS …, 2012 - journals.plos.org
The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a
cell death reaction termed heterokaryon incompatibility. This reaction is observed at the …

Atypical resistance protein RPW8/HR triggers oligomerization of the NLR immune receptor RPP7 and autoimmunity

L Li, A Habring, K Wang, D Weigel - Cell host & microbe, 2020 - cell.com
In certain plant hybrids, immunity signaling is initiated when immune components interact in
the absence of a pathogen trigger. In Arabidopsis thaliana, such autoimmunity and cell …

Emergence of the fungal immune system

A Daskalov - Iscience, 2023 - cell.com
Investigation of fungal biology has been frequently motivated by the fact that many fungal
species are important plant and animal pathogens. Such efforts have contributed …

Molecular mechanisms regulating cell fusion and heterokaryon formation in filamentous fungi

A Daskalov, J Heller, S Herzog, A Fleißner… - Microbiology …, 2017 - Am Soc Microbiol
For the majority of fungal species, the somatic body of an individual is a network of
interconnected cells sharing a common cytoplasm and organelles. This syncytial …

Diversity and variability of NOD-like receptors in fungi

W Dyrka, M Lamacchia, P Durrens… - Genome biology and …, 2014 - academic.oup.com
Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular
receptors that control innate immunity and other biotic interactions in animals and plants …

Vegetative incompatibility in fungi: From recognition to cell death, whatever does the trick

M Paoletti - Fungal Biology Reviews, 2016 - Elsevier
Allorecognition in fungi takes the form of vegetative incompatibility (VI), a process leading to
the programmed cell death of heterokaryotic cells formed after anastomosis between …

Signal transduction by a fungal NOD-like receptor based on propagation of a prion amyloid fold

A Daskalov, B Habenstein, D Martinez… - PLoS …, 2015 - journals.plos.org
In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by
activating the HET-S pore-forming protein. The HET-s β-solenoid prion fold serves as a …