[HTML][HTML] Alternatives to biological skin in permeation studies: Current trends and possibilities

R Neupane, SHS Boddu, J Renukuntla, RJ Babu… - Pharmaceutics, 2020 - mdpi.com
The transdermal route of drugs has received increased attention in recent years due to
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …

Current and future perspectives on skin tissue engineering: key features of biomedical research, translational assessment, and clinical application

JR Yu, J Navarro, JC Coburn, B Mahadik… - Advanced …, 2019 - Wiley Online Library
The skin is responsible for several important physiological functions and has enormous
clinical significance in wound healing. Tissue engineered substitutes may be used in …

Benzalkonium chloride: an irritant and sensitizer

J Isaac, PL Scheinman - Dermatitis, 2017 - liebertpub.com
Background Benzalkonium chloride (BAK) is a known irritant, and potentially cross-reacting
quaternary ammonium compounds are commonly used as preservatives in personal care …

Bioengineered skin intended as in vitro model for pharmacosmetics, skin disease study and environmental skin impact analysis

R Sanabria-de la Torre, A Fernández-González… - Biomedicines, 2020 - mdpi.com
This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS)
applications. At the first moment, they were created as an attempt to replace native skin …

In Vitro Models for Studying Transport Across Epithelial Tissue Barriers

N Arumugasaamy, J Navarro, J Kent Leach… - Annals of biomedical …, 2019 - Springer
Epithelial barriers are the body's natural defense system to regulating passage from one
domain to another. In our efforts to understand what can and cannot cross these barriers …

Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption

T Brackin, H Gayes, I Johnson, D Fox, C Roper - Toxicology in Vitro, 2024 - Elsevier
In vitro absorption through human skin is a critical component in the safety assessment of
chemicals, crop protection products, consumer healthcare products and cosmetics. A barrier …

Ex vivo penetration analysis and anti-inflammatory efficacy of the association of ferulic acid and UV filters

R Sauce, CAS de Oliveira Pinto, MVR Velasco… - European Journal of …, 2021 - Elsevier
Background Unprotected chronic exposure to ultraviolet (UV) radiation generates many
harmful effects to human skin and sunscreens are essential to health, however, traditional …

Bioequivalence of topical generic products. Part 2. Paving the way to a tailored regulatory system

M Miranda, JJ Sousa, F Veiga, C Cardoso… - European Journal of …, 2018 - Elsevier
Hitherto, for the approval of a topical generic drug product, the majority of the regulatory
agencies require clinical endpoint studies to prove its therapeutic equivalence in relation to …

Tracing skin aging process: A mini-review of in vitro approaches

S Letsiou - Biogerontology, 2021 - Springer
Skin is a rather complex, yet useful organ of our body. Besides, skin aging is a complicated
process that gains a growing interest as mediates many molecular processes in our body …

Advances in polymeric nano-delivery systems targeting hair follicles for the treatment of acne

Y Lei, W Jiang, C Peng, D Wu, J Wu, Y Xu, H Yan… - Drug Delivery, 2024 - Taylor & Francis
Acne is a common chronic inflammatory disorder of the sebaceous gland in the hair follicle.
Commonly used external medications cause skin irritation, and the transdermal capacity is …