Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although
extensive strides have been made in the treatments for non-diabetic atherosclerosis and its …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

Deep venous thrombosis (DVT) is one of the most common cardiovascular diseases, but its
pathophysiology remains incompletely understood. Although sterile inflammation has …

Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Platelets have long been known for their role in hemostasis. In this, platelet adhesion and
activation leads to the formation of a firm thrombus and thus the sealing of a damaged blood …

Neutrophil extracellular traps (NETs) comprise decondensed chromatin, histones and
neutrophil granular proteins and are involved in the response to infectious as well as non …