Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of
leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly) …

Caffeic acid is one of the most abundant hydroxycinnamic acids in fruits, vegetables, and
beverages. This phenolic compound reaches relevant concentrations in the colon (up to 126 …

Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …

Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …

Oxidized phospholipids are found in the vasculature of animal models of atherosclerosis, in
human atherosclerotic lesions, and in other inflammatory diseases. Oxidized phospholipids …

Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and
cytochrome P450 are important lipid mediators involved in numerous homeostatic and …

Background Hypoxia-inducible factor-1α (HIF-1α) is an important transcription factor that
modulates cellular responses to hypoxia and also plays critical roles in cancer progression …

The biosynthetic crossover of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2)
enzymatic activities is a productive pathway to convert arachidonic acid into unique …

Scope Urolithins (Uro), gut microbial metabolites derived from ellagic acid (EA), reach
significant concentrations in the human colon. Uro‐A exerts anti‐inflammatory activity in …