Abstract The site-1 and site-2 proteases (S1P and S2P) were identified over 20 years ago,
and the functions of both have been addressed in numerous studies ever since. Whereas …

Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol
has long been suspected of influencing hair growth. Altered cholesterol homeostasis is …

Keratosis pilaris is a common skin disorder comprising less common variants and rare
subtypes, including keratosis pilaris rubra, erythromelanosis follicularis faciei et colli, and the …

TRPV3, a non-selective cation channel known to be activated by physiological temperature,
is expressed in skin and is involved in different skin functions. Point mutations in TRPV3 …

The MBTPS2 gene on the X-chromosome encodes the membrane-bound transcription factor
protease, site-2 (MBTPS2) or site-2 protease (S2P) which cleaves and activates several …

BACKGROUND Colorectal cancer (CRC) is a common malignant tumor of the
gastrointestinal tract. Lipid metabolism, as an important part of material and energy …

Ichthyosis follicularis, atrichia and photophobia syndrome (IFAP) is an X‐linked inherited
disease caused by pathogenic variants in the gene encoding the membrane‐bound …

The epidermis plays an indispensable barrier function in animals. Some species have
evolved unique epidermal structures to adapt to different environments. Aquatic and semi …

Ichthyosis follicularis with atrichia and photophobia (IFAP) syndrome is a rare
genodermatosis characterized by a classic triad of follicular ichthyosis, alopecia, and …

Background The ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare
X‐linked genodermatosis characterized by noninflammatory spiny follicular hyperkeratosis …