In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

ATP is an endothelium-dependent vasodilator, and findings regarding the underlying
signaling mechanisms are equivocal. We sought to determine the independent and …

ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y.
Activation of P2X receptors has traditionally been associated with the well‐characterised …

ATP is an important endogenous mediator in the cardiovascular system. It induces
endothelium dependent vasodilation, but the precise receptor pathway activated in this …

Adenosine was identified as a regulator of skeletal muscle blood flow almost 50 years ago. It
was first proposed that increased use of ATP during muscle contractions led to net ATP …

Heme oxygenase is the rate-limiting enzyme in the catabolism of heme to carbon monoxide,
bilirubin and free iron. Many cell types express heme oxygenase-2 constitutively while heme …

Cannabinoids (natural, endogenous and synthetic compounds) produce vasorelaxation in
resistance and conduit arteries. Several putative mechanisms have been proposed to …

This study aimed to examine the expression and function of P2 receptors of the rat tail and
mesenteric arteries during maturation and ageing (4, 6 and 12weeks, 8 and 24months) …

Rimonabant is an inverse agonist specific for cannabinoid receptors and selective for their
cannabinoid-1 (CB 1) subtype. Although CB 1 receptors are more abundant in the central …