Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions

A Korniluk, OM Koper-Lenkiewicz… - Mediators of …, 2019 - Wiley Online Library
Platelet size has been demonstrated to reflect platelet activity and seems to be a useful
predictive and prognostic biomarker of cardiovascular events. It is associated with a variety …

Machine learning in cardiovascular medicine: are we there yet?

K Shameer, KW Johnson, BS Glicksberg, JT Dudley… - Heart, 2018 - heart.bmj.com
Artificial intelligence (AI) broadly refers to analytical algorithms that iteratively learn from
data, allowing computers to find hidden insights without being explicitly programmed where …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

W Zhou, JB Nielsen, LG Fritsche, R Dey… - Nature …, 2018 - nature.com
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks,
most binary traits have substantially fewer cases than controls. Both of the widely used …

Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos

MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Unravelling the human genome–phenome relationship using phenome-wide association studies

WS Bush, MT Oetjens, DC Crawford - Nature Reviews Genetics, 2016 - nature.com
Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

New roles for mean platelet volume measurement in the clinical practice?

P Noris, F Melazzini, CL Balduini - Platelets, 2016 - Taylor & Francis
Several hundreds of studies recently investigated mean platelet volume (MPV) as measured
by electronic cell counters in a wide variety of acquired diseases, and most of them found …

Predictive modeling of hospital readmission rates using electronic medical record-wide machine learning: a case-study using Mount Sinai heart failure cohort

K Shameer, KW Johnson, A Yahi, R Miotto… - Pacific symposium on …, 2017 - World Scientific
Reduction of preventable hospital readmissions that result from chronic or acute conditions
like stroke, heart failure, myocardial infarction and pneumonia remains a significant …

Electronic health records-driven phenotyping: challenges, recent advances, and perspectives

J Pathak, AN Kho, JC Denny - Journal of the American Medical …, 2013 - academic.oup.com
With the completion of the Human Genome Project1 as well as recent advances in genomic
science and comparative biological studies, a new era of individualized medicine is evolving …

[HTML][HTML] Large and small platelets—(When) do they differ?

S Handtke, T Thiele - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
Platelets are most important in providing cellular hemostasis but also take part in
inflammation and immune processes. Increased platelet size has been regarded as a …