Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …

DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

We set out to design, synthesize, and optimize a DNA-minimal cage capable of
encapsulating oligonucleotide drugs to facilitate their delivery. Through rational design and …

Nucleic acid nanomaterials with good biocompatibility, biodegradability, and
programmability have important applications in biomedical field. Nucleic acid nanomaterials …

The development of controlled/living polymerization methodologies has underpinned a
rapid expanse in our understanding of amphiphilic block copolymer self-assembly. In …

DNA nanostructures have shown potential in cancer therapy. However, their clinical
application is hampered by the difficulty to deliver them into cancer cells and susceptibility to …

Nature uses a combination of non-covalent interactions to create a hierarchy of complex
systems from simple building blocks. One example is the selective association of the …

Inspired by biological polymers, sequence‐controlled synthetic polymers are highly
promising materials that integrate the robustness of synthetic systems with the information …

Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups,
have been widely used in programmable bioengineering. Since nucleic acids are …