VHL, the story of a tumour suppressor gene
L Gossage, T Eisen, ER Maher - Nature Reviews Cancer, 2015 - nature.com
Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
Regulation of erythropoiesis by hypoxia-inducible factors
VH Haase - Blood reviews, 2013 - Elsevier
A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …
[HTML][HTML] The many facets of erythropoietin physiologic and metabolic response
S Suresh, PK Rajvanshi, CT Noguchi - Frontiers in physiology, 2020 - frontiersin.org
In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …
erythropoiesis, and hypoxia induction of EPO production provides for the important …
[HTML][HTML] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An …
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An …
Role of VHL Gene Mutation in Human Cancer
WY Kim, WG Kaelin - Journal of clinical oncology, 2004 - ascopubs.org
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …
Erythropoietin
HF Bunn - Cold Spring Harbor perspectives in …, 2013 - perspectivesinmedicine.cshlp.org
During the past century, few proteins have matched erythropoietin (Epo) in capturing the
imagination of physiologists, molecular biologists, and, more recently, physicians and …
imagination of physiologists, molecular biologists, and, more recently, physicians and …
Lineage-specific hematopoietic growth factors
K Kaushansky - New England Journal of Medicine, 2006 - Mass Medical Soc
Lineage-Specific Hematopoietic Growth Factors | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …
content The New England Journal of Medicine homepage Advanced Search SEARCH …
Genetic analysis of von Hippel‐Lindau disease
M Nordstrom‐O'Brien, RB van der Luijt… - Human …, 2010 - Wiley Online Library
Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …
A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis
MJ Percy, PW Furlow, GS Lucas, X Li… - … England Journal of …, 2008 - Mass Medical Soc
Hypoxia-inducible factor (HIF) α, which has three isoforms, is central to the continuous
balancing of the supply and demand of oxygen throughout the body. HIF-α is a transcription …
balancing of the supply and demand of oxygen throughout the body. HIF-α is a transcription …
Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not …
VR Gordeuk, AI Sergueeva, GY Miasnikova, D Okhotin… - Blood, 2004 - ashpublications.org
Adaptation to hypoxia is critical for survival and regulates multiple processes, including
erythropoiesis and vasculogenesis. Chuvash polycythemia is a hypoxia-sensing disorder …
erythropoiesis and vasculogenesis. Chuvash polycythemia is a hypoxia-sensing disorder …