Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
Fibromyalgia: a critical and comprehensive review
AT Borchers, ME Gershwin - Clinical reviews in allergy & immunology, 2015 - Springer
Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …
classification. It is often considered as part of the global overview of functional somatic …
[HTML][HTML] Genetic predictors of human chronic pain conditions
K Zorina-Lichtenwalter, CB Meloto, S Khoury… - Neuroscience, 2016 - Elsevier
Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …
The phenotypic and genetic signatures of common musculoskeletal pain conditions
Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in
affected individuals and are characterized by a report of pain greater than expected based …
affected individuals and are characterized by a report of pain greater than expected based …
Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis
A Tammimäki, PT Männistö - Pharmacogenetics and genomics, 2012 - journals.lww.com
In human studies, low COMT (catechol-O-methyltransferase) activity has been associated
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …
Pain sensitivity in fibromyalgia is associated with catechol‐O‐methyltransferase (COMT) gene
M Martínez‐Jauand, C Sitges… - … Journal of Pain, 2013 - Wiley Online Library
Background Recent evidence suggests that genetic factors might contribute to individual
differences in pain sensitivity, risk for developing clinical pain conditions and efficacy of pain …
differences in pain sensitivity, risk for developing clinical pain conditions and efficacy of pain …
[HTML][HTML] Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort …
Genetic risk factors are believed to combine with environmental exposures and contribute to
the risk of developing temporomandibular disorder (TMD). In this prospective cohort study …
the risk of developing temporomandibular disorder (TMD). In this prospective cohort study …
A Comprehensive review of the genetic and epigenetic contributions to the development of fibromyalgia
EA Ovrom, KA Mostert, S Khakhkhar, DP McKee… - Biomedicines, 2023 - mdpi.com
This narrative review summarizes the current knowledge of the genetic and epigenetic
contributions to the development of fibromyalgia (FM). Although there is no single gene that …
contributions to the development of fibromyalgia (FM). Although there is no single gene that …
[HTML][HTML] New insights into the genetics of fibromyalgia
DJ Park, SS Lee - The Korean journal of internal medicine, 2017 - ncbi.nlm.nih.gov
Although debate on the concept of fibromyalgia (FM) has been vigorous ever since the
classification criteria were first published, FM is now better understood and has become …
classification criteria were first published, FM is now better understood and has become …
The anxiodepressive comorbidity in chronic pain
The epidemiological studies report a high prevalence of mood disorders in patients with
chronic pain, and these consequences of pain can be preclinically modeled. This …
chronic pain, and these consequences of pain can be preclinically modeled. This …