Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in
affected individuals and are characterized by a report of pain greater than expected based …

In human studies, low COMT (catechol-O-methyltransferase) activity has been associated
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …

Background Recent evidence suggests that genetic factors might contribute to individual
differences in pain sensitivity, risk for developing clinical pain conditions and efficacy of pain …

Genetic risk factors are believed to combine with environmental exposures and contribute to
the risk of developing temporomandibular disorder (TMD). In this prospective cohort study …

This narrative review summarizes the current knowledge of the genetic and epigenetic
contributions to the development of fibromyalgia (FM). Although there is no single gene that …

Although debate on the concept of fibromyalgia (FM) has been vigorous ever since the
classification criteria were first published, FM is now better understood and has become …

The epidemiological studies report a high prevalence of mood disorders in patients with
chronic pain, and these consequences of pain can be preclinically modeled. This …