Recent overview of the use of iPSCs Huntington's disease modeling and therapy
M Csobonyeiova, S Polak, L Danisovic - International Journal of …, 2020 - mdpi.com
Huntington's disease (HD) is an inherited, autosomal dominant, degenerative disease
characterized by involuntary movements, cognitive decline, and behavioral impairment …
characterized by involuntary movements, cognitive decline, and behavioral impairment …
iPSCs in neurodegenerative disorders: A unique platform for clinical research and personalized medicine
S Pandey, M Jirásko, J Lochman, A Chvátal… - Journal of personalized …, 2022 - mdpi.com
In the past, several animal disease models were developed to study the molecular
mechanism of neurological diseases and discover new therapies, but the lack of equivalent …
mechanism of neurological diseases and discover new therapies, but the lack of equivalent …
AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats
S Zhu, Y Ying, J Ye, M Chen, Q Wu, H Dou, W Ni… - Cell death & …, 2021 - nature.com
Neural stem cell (NSCs) transplantation has been one of the hot topics in the repair of spinal
cord injury (SCI). Fibroblast growth factor (FGF) is considered a promising nerve injury …
cord injury (SCI). Fibroblast growth factor (FGF) is considered a promising nerve injury …
Enhancement of neural regeneration as a therapeutic strategy for Alzheimer's disease
J Gao, L Li - Experimental and Therapeutic Medicine, 2023 - spandidos-publications.com
Abstract Alzheimer's disease (AD), the most common cause of dementia worldwide, has
gradually become a global health concern for society and individuals with the process of …
gradually become a global health concern for society and individuals with the process of …
The role of exosomes and exosomal noncoding RNAs from different cell sources in spinal cord injury
ZL Yang, J Rao, FB Lin, ZY Liang, XJ Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) not only affects the quality of life of patients but also poses a heavy
burden on their families. Therefore, it is essential to prevent the occurrence of SCI; for …
burden on their families. Therefore, it is essential to prevent the occurrence of SCI; for …
hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice
D Kong, B Feng, AE Amponsah, J He, R Guo… - Stem cell research & …, 2021 - Springer
Background Spinal cord injury (SCI) is a common disease that results in motor and sensory
disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic …
disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic …
Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model
H Xiao, O Amarsaikhan, Y Zhao, X Yu, X Hu… - … Therapy-Nucleic Acids, 2023 - cell.com
Traumatic brain injury (TBI) induces pro-inflammatory polarization of astrocytes and causes
secondary disruption of the blood-brain barrier (BBB) and brain damage. Herein, we report a …
secondary disruption of the blood-brain barrier (BBB) and brain damage. Herein, we report a …
Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres
S Wang, L Wang, Q Bu, Q Wei, L Jiang, Y Dai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
Insights into human-induced pluripotent stem cell-derived astrocytes in neurodegenerative disorders
Most neurodegenerative disorders have complex and still unresolved pathology
characterized by progressive neuronal damage and death. Astrocytes, the most-abundant …
characterized by progressive neuronal damage and death. Astrocytes, the most-abundant …
Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment
R Yang, J Pan, Y Wang, P Xia, M Tai… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …