Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Hydrogel‐based growth factor delivery platforms: strategies and recent advances

BH Shan, FG Wu - Advanced Materials, 2024 - Wiley Online Library
Growth factors play a crucial role in regulating a broad variety of biological processes and
are regarded as powerful therapeutic agents in tissue engineering and regenerative …

Fracture-related infection

TF Moriarty, WJ Metsemakers, M Morgenstern… - Nature Reviews …, 2022 - nature.com
Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-
threating event. Modern orthopaedic trauma surgery, combined with innovation in medical …

Poly Ethylene Glycol (PEG)‐Based Hydrogels for Drug Delivery in Cancer Therapy: A Comprehensive Review

Z Wang, Q Ye, S Yu, B Akhavan - Advanced healthcare …, 2023 - Wiley Online Library
Hydrogel‐based drug delivery systems (DDSs) can leverage therapeutically beneficial
outcomes in cancer therapy. In this domain, polyethylene glycol (PEG) has become …

Flourishing antibacterial strategies for osteomyelitis therapy

X Wang, M Zhang, T Zhu, Q Wei, G Liu… - Advanced …, 2023 - Wiley Online Library
Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic
microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis …

[HTML][HTML] Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity

J Li, J Ma, H Sun, M Yu, H Wang, Q Meng, Z Li… - Science …, 2023 - science.org
Implant-associated infection is a major threat affecting the success of orthopedic surgeries.
Although various materials scavenge bacteria by generating reactive oxygen species (ROS) …

[HTML][HTML] Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

S Sun, Y Cui, B Yuan, M Dou, G Wang, H Xu… - … in bioengineering and …, 2023 - frontiersin.org
Drug delivery systems composed of osteogenic substances and biological materials are of
great significance in enhancing bone regeneration, and appropriate biological carriers are …

Polydopamine‐mediated interfacial functionalization of implants for accelerating infected bone repair through light‐activatable antibiosis and carbon monoxide gas …

Z Yuan, J Wu, Z Fu, S Meng, L Dai… - Advanced Functional …, 2022 - Wiley Online Library
Current treatments for implant‐associated infection remain unsatisfactory due to secondary
infection and excessive inflammation, which impairs osseointegration. Herein, an interfacial …