Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

Background Human mesenchymal cells are culprit factors in vascular (patho) physiology
and are hallmarked by phenotypic and functional heterogeneity. At present, they are …

Abstract Background and Aim Portal vein thrombosis (PVT) is a common complication of
cirrhosis. The exact pathophysiology remains largely unknown, and treatment with …

Background—Tissue factor (TF) and coagulation proteases are involved in promoting
atherosclerosis, but the molecular and cellular bases for their involvement are unknown …

Background The intimal hyperplasia (IH) and vascular remodelling that follows
endovascular injury, for instance after post-angioplasty re-stenosis, results in downstream …

Here we show that distinct subpopulations of cells exist within traumatic human extremity
wounds, each having the ability to differentiate into multiple cells types in vitro. A crude cell …

Half of the patients who present with unstable angina (UA) develop recurrent symptoms over
the subsequent year. Identification of patients destined to develop such adverse events …

The CD34 protein is regarded as a marker of stem cells from multiple origins. Recently a
mesenchymal progenitor CD34 positive cell identified from traumatized human skeletal …

Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We
previously showed that fibrocytes are mobilized into the circulation after vascular injury …

In patients with liver diseases, the liver has a reduced capacity to produce pro-and
antihemostatic proteins. This results in a rebalanced hemostatic system, which remains …