According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …

An algorithm for the assignment of phosphorylation sites in peptides is described. The
program uses tandem mass spectrometry data in conjunction with the respective peptide …

Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …

Cell signaling mechanisms often transmit information via posttranslational protein
modifications, most importantly reversible protein phosphorylation. Here we develop and …

Signalling networks regulate essentially all of the biology of cells and organisms in normal
and disease states. Signalling is often studied using antibody-based techniques such as …

The success in profiling the phosphoproteome by mass spectrometry-based proteomics has
been intimately related to the availability of methods that selectively enrich for …

The Maillard reaction, starting from the glycation of protein and progressing to the formation
of advanced glycation end-products (AGEs), is implicated in the development of …

Protein phosphorylation is a key regulator of cellular signaling pathways. It is involved in
most cellular events in which the complex interplay between protein kinases and protein …

Reduction and alkylation of cysteine residues is part of virtually any proteomics workflow.
Despite its frequent use, up to date no systematic investigation of the impact of different …