Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Gestational trophoblastic disease encompasses a range of pregnancy-related disorders,
consisting of the premalignant disorders of complete and partial hydatidiform mole, and the …

Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and
gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site …

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat
containing, or NOD-like receptor) proteins is in inflammasome activation, which has been …

Inflammation, a vital response of the immune system to infection and damage to tissues, can
be initiated by various germline-encoded innate immune-signaling receptors. Among these …

We used a machine learning approach to analyze the within-gene distribution of missense
variants observed in hereditary conditions and cancer. When applied to 840 genes from the …

Human-imprinting disorders are congenital disorders of growth, development and
metabolism, associated with disturbance of parent of origin-specific DNA methylation at …

Familial biparental hydatidiform mole (FBHM) is the only known pure maternal-effect
recessive inherited disorder in humans. Affected women, although developmentally normal …

Background Genomic imprinting results from the resistance of germline epigenetic marks to
reprogramming in the early embryo for a small number of mammalian genes. Genetic …

Nucleotide‐binding oligomerization domain (NOD) and leucine‐rich repeat (LRR)‐
containing receptors or NOD‐like receptors (NLRs) are cytosolic pattern recognition …