Background: Multicomponent reactions are one-pot processes for the synthesis of highly
functionalized hetero-cyclic and hetero-acyclic compounds, often endowed with biological …

An efficient multi-component synthesis of dihydrofurans is described by a one-pot
condensation reaction of 2, 4′-dibromoacetophenone, aromatic aldehydes and dimedone …

A novel approach for the synthesis of unprecedented C3-mono-functionalized indolin-2-
ones is reported, starting from 2-oxindole and chalcones. The reactions proceed …

The design of β-cyclodextrin/multiwalled carbon nanotubes hybrid (β-CD-MWCNT) as
nanoplatform for the entrapment and delivery of guanine based drugs is described here. The …

A new tetrahydroindazolylbenzamide derivative has been synthesized, characterized, and
evaluated as HIV-inhibitor. The biological data revealed the ability to inhibit HIV proliferation …

In an effort to identify novel molecular warheads able to inhibit Leishmania mexicana
cysteine protease CPB2. 8ΔCTE, fused benzo [b] thiophenes and β, βʹ‐triketones emerged …

Drug resistance and emergence of new pathogens highlight the need for developing new
therapeutic agents. We focused on 2-oxonicotinonitrile (2-ONN) as derivative of the natural …

A new method for the preparation of highly functionalized β-enamino diones has been
developed. The protocol involves an initial self-catalyzed Mannich-type reaction of …

A simple, straightforward and versatile multicomponent synthetic protocol for indeno-fused
heterocycles, namely diindeno [1, 2-b: 2′, 1′-e] pyridine, indeno [1, 2-b] quinoline and …

A straightforward transformation of indole-3, 4-diones is reported. The reaction feasibility is
evidenced by kinetic studies on a model substrate, revealing a double phase process with a …