The microbiota and the gut–liver axis in primary sclerosing cholangitis

JR Hov, TH Karlsen - Nature Reviews Gastroenterology & Hepatology, 2023 - nature.com
Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

The role of gut microbiota in some liver diseases: from an immunological perspective

L Wang, ZM Cao, LL Zhang, J Li, W Lv - Frontiers in immunology, 2022 - frontiersin.org
Gut microbiota is a microecosystem composed of various microorganisms. It plays an
important role in human metabolism, and its metabolites affect different tissues and organs …

Treatment of dyslipidemia through targeted therapy of gut microbiota

B Flaig, R Garza, B Singh, S Hamamah, M Covasa - Nutrients, 2023 - mdpi.com
Dyslipidemia is a multifaceted condition with various genetic and environmental factors
contributing to its pathogenesis. Further, this condition represents an important risk factor for …

The gut microbiome in disorders of gut–brain interaction

N Kraimi, T Ross, J Pujo, G De Palma - Gut Microbes, 2024 - Taylor & Francis
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either
abdominal pain, altered intestinal motility, or their combination, have a worldwide …

Expression and clinical significance of short-chain fatty acids in pregnancy complications

S Chen, J Li, S Ren, Y Gao, Y Zhou… - Frontiers in Cellular and …, 2023 - frontiersin.org
Objective To investigate the expression of short-chain fatty acids (SCFAs)—metabolites of
intestinal flora—in gestational complications of gestational diabetes mellitus (GDM) …

The black box orchestra of gut bacteria and bile acids: who is the conductor?

S Majait, M Nieuwdorp, M Kemper… - International journal of …, 2023 - mdpi.com
Over the past decades the potential role of the gut microbiome and bile acids in type 2
diabetes mellitus (T2DM) has been revealed, with a special reference to low bacterial alpha …

[PDF][PDF] Immunologic responses and the pathophysiology of primary biliary cholangitis

R Chen, R Tang, X Ma, ME Gershwin - Clinics in Liver Disease, 2022 - Elsevier
Primary biliary cholangitis (PBC) is an autoimmune liver disease with striking female
predisposition, and selective destruction of intrahepatic small bile ducts leading to non …

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

L Martinez-Gili, A Pechlivanis, JAK McDonald… - Gut …, 2023 - Taylor & Francis
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic
acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk …

Role of the gut–liver axis in the pathobiology of cholangiopathies: Basic and clinical evidence

MC Bragazzi, R Venere, A Vignone, D Alvaro… - International Journal of …, 2023 - mdpi.com
The “Gut–Liver Axis” refers to the physiological bidirectional interplay between the gut and
its microbiota and the liver which, in health, occurs thanks to a condition of immune …

Gut microbiota-derived butyrate induces epigenetic and metabolic reprogramming in myeloid-derived suppressor cells to alleviate primary biliary cholangitis

R Wang, B Li, B Huang, Y Li, Q Liu, Z Lyu, R Chen… - Gastroenterology, 2024 - Elsevier
Background & Aims Gut dysbiosis and myeloid-derived suppressor cells (MDSCs) are
implicated in primary biliary cholangitis (PBC) pathogenesis. However, it remains unknown …