Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

T cell immunity directed against tumor-encoded amino acid substitutions occurs in some
melanoma patients. This implicates missense mutations as a source of patient-specific …

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …

Mercury is a toxic and hazardous metal that occurs naturally in the earth's crust. Natural
phenomena such as erosion and volcanic eruptions, and anthropogenic activities like metal …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Systemic lupus erythematosus is a multisystem autoimmune disease in which the
autoantibody response targets a variety of autoantigens of diverse subcellular location. We …

Aseptic loosening and other wear-related complications are some of the most frequent late
reasons for revision of total knee arthroplasty (TKA). Periprosthetic osteolysis (PPOL) pre …

▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

The immune system has developed a variety of mecharmisms for sensing the presence of
invading microorganisms, which must be accomplished in the face of special topological …