Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Alzheimer's disease (AD) is a degenerative disease of the nervous system. Glucagon-like
peptide-1 receptor agonists (GLP-1 RAs), a drug used to treat type 2 diabetes, have been …

Objective Dementia is an important disease burden among the elderly, and its occurrence
may be profoundly affected by environmental factors. Evidence of the relationship between …

The molecular causes and mechanisms of neurodegenerative diseases remain poorly
understood. A growing number of single-cell studies have implicated various neural, glial …

While there are currently over 40 replicated genes with mapped risk alleles for Late Onset
Alzheimer's disease (LOAD), the Apolipoprotein E locus E4 haplotype is still the biggest …

The Religious Order Study and Memory and Aging Project (ROSMAP) is an initiative that
integrates two longitudinal cohort studies, which have been collecting clinicopathological …

Research into Alzheimer's Disease (AD) describes a link between AD and the resident
immune cells of the brain, the microglia. Further, this suspected link is thought to have …

Modification of mRNA by methylation is involved in post-transcriptional regulation of gene
expression by affecting the splicing, transport, stability and translation of mRNA. Methylation …

Chronic pain is prevalent among aging adults. Epidemiologic evidence has demonstrated
that individuals with chronic pain have accelerated memory decline and increased …

The causative mechanisms underlying the genetic relationships of neurodegenerative
diseases with epigenetic aging and human longevity remain obscure. We aimed to detect …