Prion transmission: prion excretion and occurrence in the environment
KC Gough, BC Maddison - Prion, 2010 - Taylor & Francis
Prion diseases range from being highly infectious, for example scrapie and CWD which
show facile transmission between susceptible individuals, to showing negligible horizontal …
show facile transmission between susceptible individuals, to showing negligible horizontal …
New generation QuIC assays for prion seeding activity
CD Orru, JM Wilham, S Vascellari, AG Hughson… - Prion, 2012 - Taylor & Francis
The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils
from recombinant PrPSen has served as the basis for several relatively rapid and highly …
from recombinant PrPSen has served as the basis for several relatively rapid and highly …
Extracellular vesicles with diagnostic and therapeutic potential for prion diseases
Prion diseases (PrD) or transmissible spongiform encephalopathies (TSE) are invariably
fatal and pathogenic neurodegenerative disorders caused by the self-propagated misfolding …
fatal and pathogenic neurodegenerative disorders caused by the self-propagated misfolding …
DETECTION OF PrPCWD IN FECES FROM NATURALLY EXPOSED ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI) USING PROTEIN MISFOLDING …
B Pulford, TR Spraker, AC Wyckoff… - Journal of wildlife …, 2012 - meridian.allenpress.com
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy affecting
captive and free-ranging cervids. Currently, tests for CWD in live animals involve relatively …
captive and free-ranging cervids. Currently, tests for CWD in live animals involve relatively …
Detection of prions in the faeces of sheep naturally infected with classical scrapie
Classical scrapie is a naturally transmitted prion disease of sheep and goats. Contaminated
environments may contribute to the spread of disease and evidence from animal models has …
environments may contribute to the spread of disease and evidence from animal models has …
Environmental sources of scrapie prions
BC Maddison, CA Baker, LA Terry… - Journal of …, 2010 - Am Soc Microbiol
Ovine scrapie and cervine chronic wasting disease show considerable horizontal
transmission. Here we report that a scrapie-affected sheep farm has a widespread …
transmission. Here we report that a scrapie-affected sheep farm has a widespread …
Prions are secreted into the oral cavity in sheep with preclinical scrapie
BC Maddison, HC Rees, CA Baker… - The Journal of …, 2010 - academic.oup.com
A major concern in prion disease transmission is the spread of the disease agent by means
of secretions and excretions. We analyzed buccal swab samples obtained from preclinical …
of secretions and excretions. We analyzed buccal swab samples obtained from preclinical …
Salivary prions in sheep and deer
G Tamgüney, JA Richt, AN Hamir, JJ Greenlee… - Prion, 2012 - Taylor & Francis
Scrapie of sheep and chronic wasting disease (CWD) of cervids are transmissible prion
diseases. Milk and placenta have been identified as sources of scrapie prions but do not …
diseases. Milk and placenta have been identified as sources of scrapie prions but do not …
Detection of chronic wasting disease prions in fetal tissues of free-ranging white-tailed deer
The transmission of chronic wasting disease (CWD) has largely been attributed to contact
with infectious prions shed in excretions (saliva, urine, feces, blood) by direct animal-to …
with infectious prions shed in excretions (saliva, urine, feces, blood) by direct animal-to …
Evidence of effective scrapie transmission via colostrum and milk in sheep
T Konold, SJ Moore, SJ Bellworthy, LA Terry… - BMC veterinary …, 2013 - Springer
Background Evidence for scrapie transmission from VRQ/VRQ ewes to lambs via milk was
first reported in 2008 but in that study there were concerns that lateral transmission may …
first reported in 2008 but in that study there were concerns that lateral transmission may …