Evolution and diversity of assembly-line polyketide synthases: Focus review
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …
machineries known in nature, responsible for the biosynthesis of numerous compounds …
Practical guidance for clinical microbiology laboratories: mycobacteria
BA Forbes, GS Hall, MB Miller, SM Novak… - Clinical microbiology …, 2018 - Am Soc Microbiol
Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy,
Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most …
Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most …
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte …
MT Silva - Journal of leukocyte biology, 2010 - academic.oup.com
The presence of two dedicated phagocytic cells working cooperatively represents an
advantageous innate immune strategy that allows the efficient and safe utilization of …
advantageous innate immune strategy that allows the efficient and safe utilization of …
Impact of Mycobacterium ulcerans Biofilm on Transmissibility to Ecological Niches and Buruli Ulcer Pathogenesis
The role of biofilms in the pathogenesis of mycobacterial diseases remains largely unknown.
Mycobacterium ulcerans, the etiological agent of Buruli ulcer, a disfiguring disease in …
Mycobacterium ulcerans, the etiological agent of Buruli ulcer, a disfiguring disease in …
Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin
C Gomes, S Martínez-Puchol, N Palma… - Critical reviews in …, 2017 - Taylor & Francis
From its introduction in 1952 onwards, the clinical use of macrolides has been steadily
increasing, both in human and veterinary medicine. Although initially designed to the …
increasing, both in human and veterinary medicine. Although initially designed to the …
Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans
Buruli ulcer is an emerging human disease caused by infection with a slow-growing
pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with …
pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with …
Structural basis and designing of peptide vaccine using PE-PGRS family protein of Mycobacterium ulcerans—An integrated vaccinomics approach
Buruli ulcer is an emerging tissue-necrosis infectious disease, caused by the pathogen
Mycobacterium ulcerans, leading to permanent deformity if untreated. Despite this …
Mycobacterium ulcerans, leading to permanent deformity if untreated. Despite this …
Buruli ulcer
F Portaels, MT Silva, WM Meyers - Clinics in dermatology, 2009 - Elsevier
Buruli ulcer is an indolent necrotizing disease of the skin, subcutaneous tissue, and bone
that is caused by Mycobacterium ulcerans. Buruli ulcer is presently the third most common …
that is caused by Mycobacterium ulcerans. Buruli ulcer is presently the third most common …
The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER
BS Hall, K Hill, M McKenna, J Ogbechi, S High… - PLoS …, 2014 - journals.plos.org
Infection with Mycobacterium ulcerans is characterised by tissue necrosis and
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …
Evolution of polyketide synthases in bacteria
The emergence of resistant strains of human pathogens to current antibiotics, along with the
demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for …
demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for …