Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets.
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized
information on a rapidly expanding interdisciplinary field. User-friendly and high-quality …

Dynamic combinatorial library (DCL) has emerged as an efficient tool for ligand discovery
and become an important discovery modality in biomedical research. However, the …

Abstract e-LEA3D web server integrates three complementary tools to perform computer-
aided drug design based on molecular fragments. In drug discovery projects, there is a …

Highlights•Basic mechanism for all the discussed click reaction has been shown.•Many new
enzyme inhibitors was identified by drug discovery using click approaches.•Drug delivery by …

Nucleic acids play crucial roles in transferring cellular information and gene regulations.
DNA and RNA molecules have been associated with multiple human diseases and thus …

Protein‐templated fragment ligation is a novel concept to support drug discovery and can
help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are …

Dynamic combinatorial libraries (DCLs) is a powerful tool for ligand discovery in biomedical
research; however, the application of DCLs has been hampered by their low diversity …

Contemporary drug discovery approaches rely on library synthesis coupled with
combinatorial methods and high-throughput screening to identify leads. However, due to the …