The gonadotrophin‐releasing hormone (GnRH) neurones represent the final output
neurones of a complex neuronal network that controls fertility. It is now appreciated that …

Gonadal steroid feedback regulates the brain's patterned secretion of gonadotropin-
releasing hormone (GnRH). Negative feedback, which occurs in males and during the …

Polycystic ovary syndrome, a fertility disorder affecting≈ 7% of women, is characterized by
elevated androgens, disrupted reproductive cycles, and high luteinizing hormone, the latter …

A robust gonadotropin-releasing hormone (GnRH) surge is a prerequisite signal for the
luteinizing hormone (LH) surge that triggers ovulation. In rodents, the GnRH surge is …

Chemogenetic technologies, including the mutated human G q-coupled M3 muscarinic
receptor (hM3Dq), have greatly facilitated our ability to directly link changes in cellular …

Pulsatile GnRH release is essential to fertility and is modulated by gonadal steroids, most
likely via steroid-sensitive afferents. Arcuate neurons coexpressing kisspeptin, neurokinin B …

The M-current (IM), comprised of Kv7 channels, is a voltage-activated K+ conductance that
plays a key role in the control of cell excitability. In hippocampal principal cells, IM controls …

Neurons that produce kisspeptin play a critical role in reproduction. However, understanding
the molecular physiology of kisspeptin neurons has been limited by the lack of an in vivo …

The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons.
Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release …

Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and
subsequent luteinizing hormone (LH) release. Estradiol acts via estrogen receptor α (ERα) …