Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway

B Xu, W Dai, L Liu, H Han, J Zhang, X Du, X Pei… - Endocrine …, 2022 - jstage.jst.go.jp
Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a
variety of clinical features, including anovulation, hyperandrogenism, and ovarian …

Exploring the therapeutic potential of tonic Chinese herbal medicine for gynecological disorders: An updated review

Q He, S Wan, M Jiang, W Li, Y Zhang, L Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Gynecological disorders have the characteristics of high
incidence and recurrence rate, which sorely affects female's health. Since ancient times …

Metabolomics combined with network pharmacology to explore the mechanisms of modified Guishen pill to ameliorate polycystic ovary syndrome

J Tian, Y Xu, Y Xiong, L Zuo, M Zhou, C Cao… - Computers in Biology …, 2022 - Elsevier
Abstract Background The modified Guishen pill (MGP) has a prominent therapeutic effect on
polycystic ovary syndrome (PCOS). However, its mechanism is still unclear. This study …

[HTML][HTML] Cuscuta chinensis flavonoids alleviate ovarian damage in offspring female mice induced by BPA exposure during pregnancy by regulating the central carbon …

Q Zhao, Y Liu, Y Chuo, X Wang, Y Jiao, W Shi… - … and Environmental Safety, 2024 - Elsevier
Pregnancy is a sensitive window period for bisphenol A (BPA) exposure. BPA can pass
through the placenta and cause reproductive damage in offspring female mice. Even BPA …

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

AME Elkhalifa, SI Ali, SU Nabi, I Bashir, S Taifa… - Heliyon, 2024 - cell.com
Regeneration is a rare occurrence in the animal kingdom, but the earthworm stands out as a
remarkable example of this phenomenon. Recent research has highlighted the promising …

Exploring the Therapeutic Potential of Natural Products in Polycystic Ovarian Syndrome (PCOS): A Mini-Review of Lipid Profile, Blood Glucose, and Ovarian …

S Wahid, MDC Ramli, NE Fazleen, RM Naim… - Life, 2024 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is
characterized by fluid-filled sacs in the ovaries and various symptoms, including high …

Aged garlic extract preserves beta-cell functioning via modulation of nuclear factor kappa-B (NF-κB)/Toll-like receptor (TLR)-4 and sarco endoplasmic reticulum …

SI Ali, AME Elkhalifa, SU Nabi, FS Hayyat… - Diabetology & Metabolic …, 2024 - Springer
Background Peripheral insulin resistance and compromised insulin secretion from
pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM) …

Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway

OO Akintoye, AJ Ajibare, IA Oriyomi, BA Olofinbiyi… - Life Sciences, 2023 - Elsevier
Introduction Psychiatric and cognitive impairment has been observed in premenopausal
women with a hormonal disorder called polycystic ovary syndrome (PCOS). This study …

Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model

R Rani, AK Sharma, HR Chitme - Clinical Medicine Insights …, 2023 - journals.sagepub.com
Background: Tinosopora cordifolia (Willd)(TC) is commonly used in Ayurvedic medicine
since long time for number of ailments and its preparations are also considered by food …

[HTML][HTML] Evaluation of decellularized caprine small intestine submucosa encapsulated with nano-formulations of cerium oxide and curcumin in the management of …

J Li, H Li, K Wang, H Chou - Regenerative Therapy, 2024 - Elsevier
The management of burn injuries presents a significant challenge in clinical settings, yet an
optimal solution remains elusive. Therefore, this study aimed to develop a topical …