Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

The vast range and complexity of glycan structures and their dynamic variations in health
and disease have presented formidable challenges toward understanding the biological …

Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …

Programs that control immune cell homeostasis are orchestrated through the coordinated
action of a number of regulatory cell populations, including regulatory T cells, regulatory B …

The relevance of glycan-binding proteins in immune tolerance and inflammation has been
well established, mainly by studies of C-type lectins, siglecs and galectins, both in …

Cell surface glycans and their glycan-binding partners (lectins) have generally been
recognized as adhesive assemblies with neighbor cells or matrix scaffolds in organs and the …

Galectin family is a group of glycan-binding proteins. Members in this family are expressed
in different tissues, immune or non-immune cells. These molecules are important regulators …

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-
enriched glycoconjugates, modulate several immune cell processes shaping the course of …

In the last decades, the focus of cancer research has moved from epithelial cells to the tumor
milieu, in an effort to better understand tumor development and progression, and with the …