Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Heparins have been invaluable therapeutic anticoagulant polysaccharides for over a
century, whether used as unfractionated heparin or as low molecular weight heparin …

Every method used to quantify biomolecular interactions has its own strengths and
limitations. To quantify protein‐DNA binding affinities, nitrocellulose filter binding assays …

Heparan sulfate (HS) and heparin contain imprinted “sulfation codes”, which dictate their
diverse physiological and pathological functions. A group of orchestrated biosynthetic …

Abstract Roundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in
endothelial cells. Soluble Robo4 was reported in the human plasma and mouse serum and …

The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor …

Abstract Glucuronyl 5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) into L-iduronic
acid (IdoA) units, through a mechanism involving reversible abstraction of a proton at C5 of …

Building blocks characterization is a significant approach for understanding the molecular
structure of heparin and its derivatives. Nitrous acid (HONO) depolymerization of heparin …

Non-polioenteroviruses are highly infectious viruses that typically cause mild asymptomatic
cases but can cause severe disease such as aseptic meningitis and dilated cardiomyopathy …