Objective Because curcumin's anti-inflammatory properties may protect the brain from
neurodegeneration, we studied its effect on memory in non-demented adults and explored …

There is growing evidence of activated microglia and inflammatory processes in the cerebral
cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by …

Abstract 2-(1-{6-[(2-[fluorine-18] fluoroethyl)(methyl) amino]-2-naphthyl}-ethylidene)
malononitrile (FDDNP) is the first positron emission tomography (PET) molecular imaging …

Alzheimer's disease (AD) is an incurable neurodegenerative disease and the most
frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion …

Amyloid positron-emission-tomography (PET) offers an important research and diagnostic
tool for investigating Alzheimer's disease (AD). The majority of amyloid PET studies have …

Abstract Purpose A [11 C] UCB-J blocking study was performed in healthy volunteers to
validate simplified, non-invasive measures for quantifying presynaptic SV2A expression …

PET imaging of tau pathology in Alzheimer disease may benefit from the use of white matter
reference regions. These regions have shown reduced variability compared with …

[18F] FPEB is a positron emission tomography tracer which, in preclinical studies, has
shown high specificity and selectivity toward the metabotropic glutamate receptor 5 …

Beta amyloid plaques, neurofibrillary tangles, and impaired glucose metabolism are among
the most prevalent pathological characteristics of Alzheimer's disease (AD). However …

Background Semiquantitative methods such as the standardized uptake value ratio (SUVR)
require normalization of the radiotracer activity to a reference tissue to monitor changes in …