Influenza virus infection is an ongoing health and economic burden causing epidemics with
pandemic potential, affecting 5–30% of the global population annually, and is responsible …

Hepatitis C virus (HCV) is the major cause of chronic liver disease as well as the major
indication for liver transplantation worldwide. Current standard of care is not completely …

Objective The recent availability of novel antiviral drugs has raised new hope for a more
effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in …

Modern vaccines must be designed to generate long-lasting, high-affinity, and broadly
neutralizing Ab responses against pathogens. The diversity of B cell clones recruited into …

The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates
with antibodies to envelope variable region 2 (V2). We show here that vaccine-induced …

The Dengue virus complex (DENV), formed by four serotypes, constitutes the most important
arbovirus affecting humans. The structural domain III of their envelope protein (DIII) elicits …

ABSTRACT Herpes simplex virus 1 (HSV-1) and HSV-2 can evade serum antibody-
mediated neutralization through cell-to-cell transmission mechanisms, which represent one …

The current vaccine development strategies for the COVID-19 pandemic utilize whole
inactive or attenuated viruses, virus-like particles, recombinant proteins, and antigen-coding …

IgG responses are fundamental to adaptive immunity and document immunological memory
of previous pathogen encounter. While specific antigen recognition is mediated by the …

Hepatitis C virus (HCV) neutralization occurring at the E2 region 412‐426 (EP‐I) could be
enhanced when antibodies directed specifically to the E2 region 434‐446 (EP‐II) were …