Increasing focus on issues of research reproducibility affords us the opportunity to review
some of the key issues related in vivo research. First, we set out some key definitions, to …

Meta-analytic techniques have been widely used to synthesize data from animal models of
human diseases and conditions, but these analyses often face two statistical challenges due …

Results of animal experiments are used for understanding the pathophysiology of diseases,
assessing safety and efficacy of newly developed drugs, and monitoring environmental …

Background Amplifying endogenous neuroprotective mechanisms is a promising avenue for
stroke therapy. One target is mammalian target of rapamycin (mTOR), a serine/threonine …

Background Nitroglycerin has been of considerable interest as a treatment for ischaemic
stroke. Recent clinical trials with nitroglycerin transdermal patches during the acute phase of …

Since the early 1990s the number of systematic reviews (SR) of animal studies has steadily
increased. There is, however, little guidance on when and how to conduct a meta‐analysis …

Phenotyping mouse model systems of human disease has proven to be a difficult task, with
frequent poor inter‐and intra‐laboratory replicability, particularly in behavioral domains such …

ABSTRACT Introduction and objective The Western diet that comprises high levels of long-
chain saturated fats and sugar is associated not only with metabolic disorders such as …

Background and aims Chemotherapy-induced peripheral neuropathy (CIPN) can be a
severely disabling side-effect of commonly used cancer chemotherapeutics, requiring …

Fatigue may occur in undercarriages and support systems of trailers, haymakers, graders
and swing-ploughs made up of thin-walled tubular sections with wall thicknesses less than …