The medicinal chemistry of ferrocene and its derivatives

M Patra, G Gasser - Nature Reviews Chemistry, 2017 - nature.com
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …

Ferrocifen type anti cancer drugs

G Jaouen, A Vessières, S Top - Chemical Society Reviews, 2015 - pubs.rsc.org
Despite current developments in therapeutics focusing on biotechnologically-oriented
species, the unflagging utility of small molecules or peptides in medicine is still producing …

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

CC Konkankit, SC Marker, KM Knopf, JJ Wilson - Dalton Transactions, 2018 - pubs.rsc.org
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

B Bertrand, A Casini - Dalton Transactions, 2014 - pubs.rsc.org
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

A new age for iron: antitumoral ferrocenes

SS Braga, AMS Silva - Organometallics, 2013 - ACS Publications
From the core of the earth to the core of the archetypal organometallic compound ferrocene,
iron and its compounds contribute to create many aspects of our reality: the earth's …

Metal-based antitumor compounds: Beyond cisplatin

PV Simpson, NM Desai, I Casari, M Massi… - Future Medicinal …, 2019 - Taylor & Francis
Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin
lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain …

Recent advances in iron-complexes as drug candidates for cancer therapy: Reactivity, mechanism of action and metabolites

M Bouché, C Hognon, S Grandemange, A Monari… - Dalton …, 2020 - pubs.rsc.org
In this perspective, we discuss iron-complexes as drug candidates that are promising
alternatives to conventional platinum-based chemotherapies owing to their broad range of …

Anticancer and antibacterial activity of transition metal complexes

SK Nandanwar, HJ Kim - ChemistrySelect, 2019 - Wiley Online Library
Deaths caused by cancer and bacterial infection necessitate the development of new and
potential compounds with desired properties that could circumvent the problem of chemo …

Metallomics insights into the programmed cell death induced by metal-based anticancer compounds

CP Tan, YY Lu, LN Ji, ZW Mao - Metallomics, 2014 - academic.oup.com
Since the discovery of cisplatin more than 40 years ago, enormous research efforts have
been dedicated to developing metal-based anticancer agents and to elucidating the …

Multifaceted chemical behaviour of metallocene (M= Fe, Os) quinone methides. Their contribution to biology

A Vessieres, Y Wang, MJ McGlinchey… - Coordination Chemistry …, 2021 - Elsevier
Organometallic quinone methides (OM-QMs) have unique chemical and biological
properties compared to their purely organic counterparts, but their originality has not …